Detailed view for TVAG_487510

Basic information

TDR Targets ID: 857608
Trichomonas vaginalis, nucleoside diphosphate kinase, putative
Source Database / ID: 

pI: 6.1859 | Length (AA): 377 | MW (Da): 43141 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00334   Nucleoside diphosphate kinase

Gene Ontology

Mouse over links to read term descriptions.
GO:0006165   nucleoside diphosphate phosphorylation  
GO:0005524   ATP binding  
GO:0004550   nucleoside diphosphate kinase activity  
GO:0006183   GTP biosynthetic process  
GO:0006241   CTP biosynthetic process  
GO:0006228   UTP biosynthetic process  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130669)

Species Accession Gene Product
Drosophila melanogaster Dmel_CG8362   CG8362 gene product from transcript CG8362-RA
Echinococcus granulosus EgrG_000443700   non metastatic cells 7 protein expressed
Echinococcus multilocularis EmuJ_000443700   non metastatic cells 7, protein expressed
Giardia lamblia GL50803_14135   Nucleoside diphosphate kinase
Homo sapiens ENSG00000143156   NME/NM23 family member 7
Leishmania braziliensis LbrM.34.3850   nucleoside diphosphate kinase, putative
Leishmania donovani LdBPK_353910.1   nucleoside diphosphate kinase, putative
Leishmania infantum LinJ.35.3910   nucleoside diphosphate kinase, putative
Leishmania major LmjF.35.3870   nucleoside diphosphate kinase, putative
Leishmania mexicana LmxM.34.3870   nucleoside diphosphate kinase, putative
Mus musculus ENSMUSG00000026575   NME/NM23 family member 7
Neospora caninum NCLIV_022680   nucleoside diphosphate kinase 7, putative
Schistosoma japonicum Sjp_0308330   ko:K00940 nucleoside-diphosphate kinase [EC2.7.4.6], putative
Schistosoma japonicum Sjp_0107470   ko:K00940 nucleoside-diphosphate kinase [EC2.7.4.6], putative
Schistosoma mansoni Smp_153530   nucleoside diphosphate kinase
Schmidtea mediterranea mk4.001663.02   Nucleoside diphosphate kinase 7
Schmidtea mediterranea mk4.010719.04   Nucleoside diphosphate kinase 7
Trypanosoma brucei gambiense Tbg972.9.6720   nucleoside diphosphate kinase, putative
Trypanosoma brucei Tb927.9.11260   nucleoside diphosphate kinase, putative
Trypanosoma congolense TcIL3000_9_4640   nucleoside diphosphate kinase, putative
Trypanosoma cruzi TcCLB.508461.400   nucleoside diphosphate kinase
Toxoplasma gondii TGME49_202210   nucleoside diphosphate kinase
Trichomonas vaginalis TVAG_487510   nucleoside diphosphate kinase, putative
Trichomonas vaginalis TVAG_498410   nucleoside diphosphate kinase, putative

Essentiality

TVAG_487510 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb09.211.2560 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb09.211.2560 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb09.211.2560 Trypanosoma brucei significant gain of fitness in procyclic forms alsford
Tb09.211.2560 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
TGME49_202210 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TVAG_487510 (Trichomonas vaginalis), nucleoside diphosphate kinase, putative
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